Opportunity Information: Apply for PAR 24 078
PAR-24-078 is an NIH funding opportunity for a cooperative agreement (U42) that continues support for a limited set of existing specific pathogen-free (SPF) macaque breeding colonies that are already funded under earlier NIH initiatives (PAR-21-089 and PAR-18-669). The central goal is to maintain and sustain these established colonies because they provide a reliable supply of well-characterized macaques that are critical for HIV/AIDS-related research. The program is framed as a continuation effort rather than an open expansion of new colonies, which is why it is described as a limited competition.
The scientific rationale is that SPF macaques reduce confounding factors and improve safety in HIV/AIDS studies. These animals are bred and managed to be free of certain viruses that could otherwise interfere with interpretation of immunology and pathogenesis experiments, complicate comparisons across studies, or pose occupational health risks to staff working with the animals. By controlling these background infections, researchers can attribute observed outcomes more confidently to the experimental variables related to HIV/SIV research rather than to unrelated endemic pathogens.
A key feature of the colonies supported under this NOFO is genetic characterization, particularly typing for major histocompatibility complex (MHC) class I variants. MHC class I genotypes strongly influence immune responses in macaque models of Simian Immunodeficiency Virus (SIV), which is widely used to study AIDS-like disease in nonhuman primates, and these genotype effects are also relevant for understanding parallels in human HIV immunity. Maintaining colonies with known pedigrees and MHC profiles supports reproducible, appropriately powered studies, enables better experimental design (such as balancing or selecting animals by genotype), and strengthens the overall value of the macaque model for HIV/AIDS research questions.
Administratively, this opportunity uses the cooperative agreement mechanism, meaning NIH expects substantial programmatic involvement compared with a standard research grant. The NOFO is explicitly labeled "Clinical Trial Not Allowed," indicating the funded activities are intended to support colony infrastructure and related resources rather than conduct clinical trials. The activity category is health, and the listing includes CFDA numbers 93.310 and 93.351.
Eligibility is restricted. The eligible applicant type listed is public and state-controlled institutions of higher education, and foreign involvement is not permitted. Non-U.S. entities (foreign organizations) cannot apply, non-U.S. components of U.S. organizations are not eligible, and foreign components as defined by the NIH Grants Policy Statement are not allowed. This structure keeps the work fully within eligible U.S.-based institutional settings and aligns with the program's emphasis on continuing support for existing NIH-backed domestic colonies.
Key dates and identifiers provided include the Funding Opportunity Number PAR-24-078, an original closing date of January 25, 2024, and a creation date of January 9, 2024. The award ceiling and expected number of awards are not specified in the provided source text, which often indicates that budgets and award counts may depend on available appropriations, program priorities, and the scale of approved continuation activities.Apply for PAR 24 078
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: Specific Pathogen Free Macaque Colonies (U42 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310, 93.351.
- This funding opportunity was created on 2024-01-09.
- Applicants must submit their applications by 2024-01-25. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education.
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